CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases

• Main Authors: Jordan M. Wall (Author), Ankita Basu (Author), Elizabeth R. M. Zunica (Author), Olga S. Dubuisson (Author), Kathryn Pergola (Author), Joshua P. Broussard (Author), John P. Kirwan (Author), Christopher L. Axelrod (Author), Alyssa E. Johnson (Author)
• Format: Book
• Published: The Company of Biologists, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis. However, patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise e...