The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca²⁺ Entry in Pulmonary Arterial Smooth Muscle Cells

• Main Authors: Zen-Kong Dai (Author), Yi-Chen Chen (Author), Su-Ling Hsieh (Author), Jwu-Lai Yeh (Author), Jong-Hau Hsu (Author), Bin-Nan Wu (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca²⁺ concentration ([Ca²⁺]_i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonar...