Can First-Dose Therapeutic Drug Monitoring Predict the Steady State Area Under the Blood Concentration-Time Curve of Busulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation?

Can First-Dose Therapeutic Drug Monitoring Predict the Steady State Area Under the Blood Concentration-Time Curve of Busulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation?

Busulfan has high intra-individual variability and possible time-dependent changes in clearance, which complicates therapeutic drug monitoring (TDM), as first dose sampling may not predict the steady state concentrations. In this study, we aimed to use Bayesian pharmacokinetic parameters estimated f...

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Main Authors: Abdullah Alsultan (Author), Ahmed A. Albassam (Author), Abdullah Alturki (Author), Abdulrahman Alsultan (Author), Mohammed Essa (Author), Bader Almuzzaini (Author), Salman Alfadhel (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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