Role of Human Mesangial-Tubular Crosstalk in Secretory IgA-Induced IgA Nephropathy

• Main Authors: Junjun Zhang (Author), Ruwen Zhou (Author), Yiming Mi (Author), Zhangsuo Liu (Author), Bo Huang (Author), Ruxue Guo (Author), Panfei Wang (Author), Songxia Quan (Author), Yali Zhou (Author)
• Format: Book
• Published: Karger Publishers, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: IgA nephropathy (IgAN) is characterized by the mesangial deposition of pathogenic IgA. We previously detected the deposition of pathogenic secretory IgA (SIgA) in the mesangium of about one-third of IgAN patients. Tubulointerstitial injury has an important role in the development of IgAN...