Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a Way to Improve the Release Profile

• Main Authors: Radosław Balwierz (Author), Dawid Bursy (Author), Paweł Biernat (Author), Nataliia Hudz (Author), Mariia Shanaida (Author), Łukasz Krzemiński (Author), Paweł Skóra (Author), Monika Biernat (Author), Wioletta Ochędzan Siodłak (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-<i>N</i>-[(1<i>R</i>,2<i>R</i>)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an...