Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

• Prif Awduron: John A. Zebala (Awdur), Aaron D. Schuler (Awdur), Stuart J. Kahn (Awdur), Dean Y. Maeda (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares respiration. Here we show its active metabolite, de...