Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

• Main Authors: John A. Zebala (Author), Aaron D. Schuler (Author), Stuart J. Kahn (Author), Dean Y. Maeda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares respiration. Here we show its active metabolite, de...