Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

• Hauptverfasser: Thomas Müller (Verfasst von), Carolin Tasser (Verfasst von), Michael Tesar (Verfasst von), Ivica Fucek (Verfasst von), Ute Schniegler-Mattox (Verfasst von), Joachim Koch (Verfasst von), Kristina Ellwanger (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ABSTRACTA challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding to the neonatal Fc receptor (FcRn). Nu...