Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

• Główni autorzy: Thomas Müller (Autor), Carolin Tasser (Autor), Michael Tesar (Autor), Ivica Fucek (Autor), Ute Schniegler-Mattox (Autor), Joachim Koch (Autor), Kristina Ellwanger (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

ABSTRACTA challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding to the neonatal Fc receptor (FcRn). Nu...