Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

• Main Authors: Melissa J. Chee (Author), Alex J. Hebert (Author), Nadege Briançon (Author), Stephen E. Flaherty, III (Author), Pavlos Pissios (Author), Eleftheria Maratos-Flier (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state. Since MCHR1 expression is widespread, the neurons...