PBPK Evaluation of Sofosbuvir Dose in Pediatrics Using Simcyp^®

• Main Authors: Rania Elkeeb (Author), Anomeh Avartoomian (Author), Amira S. Gouda (Author), Ahmed M. Abdel-Megied (Author), Ola Abdallah (Author), Eman Atef (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study is to evaluate the effectiveness of the pediatric sofosbuvir weight-based dosing strategy in providing an equitable drug exposure compared to the marketed dose. The physiologically based pharmacokinetic (PBPK) modeling and simulation is a valuable tool in assessing drug dosing a...