DNA damage response in breast cancer and its significant role in guiding novel precise therapies

• Main Authors: Jiayi Li (Author), Ziqi Jia (Author), Lin Dong (Author), Heng Cao (Author), Yansong Huang (Author), Hengyi Xu (Author), Zhixuan Xie (Author), Yiwen Jiang (Author), Xiang Wang (Author), Jiaqi Liu (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic instability, and tumor development. Conversely, DDR...