Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

• Main Authors: Lucia Russo (Author), Harrison T. Muturi (Author), Hilda E. Ghadieh (Author), Alexander M. Wisniewski (Author), Eric E. Morgan (Author), Syed S. Quadri (Author), Gavin P. Landesberg (Author), Helmy M. Siragy (Author), Guillermo Vazquez (Author), Rosario Scalia (Author), Rajesh Gupta (Author), Sonia M. Najjar (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood...