Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

• Κύριοι συγγραφείς: Lucia Russo (Συγγραφέας), Harrison T. Muturi (Συγγραφέας), Hilda E. Ghadieh (Συγγραφέας), Alexander M. Wisniewski (Συγγραφέας), Eric E. Morgan (Συγγραφέας), Syed S. Quadri (Συγγραφέας), Gavin P. Landesberg (Συγγραφέας), Helmy M. Siragy (Συγγραφέας), Guillermo Vazquez (Συγγραφέας), Rosario Scalia (Συγγραφέας), Rajesh Gupta (Συγγραφέας), Sonia M. Najjar (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2018-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Objective: Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood...