Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

• Main Authors: Antonio Molinaro (Author), Ara Koh (Author), Hao Wu (Author), Marc Schoeler (Author), Maria Ilaria Faggi (Author), Alba Carreras (Author), Anna Hallén (Author), Fredrik Bäckhed (Author), Robert Caesar (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Gut-derived inflammatory factors can impair glucose homeostasis, but the underlying mechanisms are not fully understood. In this study, we investigated how hepatic gene expression is regulated by gut colonization status through myeloid differentiation primary response 88 (MYD88) and how o...