Low concentrations of clarithromycin upregulate cellular antioxidant enzymes and phosphorylation of extracellular signal-regulated kinase in human small airway epithelial cells

Abstract Background It is well known that low-dose, long-term macrolide therapy is effective against chronic inflammatory airway diseases. Oxidative stress is considered to be a key pathogenesis factor in those diseases. However, the mechanism of action of low-dose, long-term macrolide therapy remai...

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Main Authors: Kuninori Iwayama (Author), Junpei Kimura (Author), Aya Mishima (Author), Ayuko Kusakabe (Author), Ko-ichi Ohtaki (Author), Yoshiko Tampo (Author), Nobumasa Hayase (Author)
Format: Book
Published: BMC, 2018-09-01T00:00:00Z.
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