P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model

• Main Authors: Mariana Torrente Gonçalves (Author), Carla Cristina Squaiella-Baptistão (Author), Giselle Pidde (Author), Priscila Hess Lopes (Author), Iseu da Silva Nunes (Author), Denise V. Tambourgi (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-MAPA is a complex compound, derived from Aspergillus oryzae cultures, that has shown immunomodulatory properties in infection and cancer animal models. Despite promising results in these models, the mechanisms of cellular activation by P-MAPA, suggested to be Toll-like receptor- (TLR-) dependent,...