Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator

• Main Authors: Udoamaka Ezuruike (Author), Mian Zhang (Author), Amita Pansari (Author), Mailys De Sousa Mendes (Author), Xian Pan (Author), Sibylle Neuhoff (Author), Iain Gardner (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The Simcyp Simulator is a software platform for population physiologically‐based pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption, distribution, metabolism, excretion and pharmacokinetic/pharmacodynamic outcomes to explore clinical scenarios and s...