Consensus guidelines on the construct validity of rodent models of restless legs syndrome

• Main Authors: Aaro V. Salminen (Author), Stefan Clemens (Author), Diego García-Borreguero (Author), Imad Ghorayeb (Author), Yuqing Li (Author), Mauro Manconi (Author), William Ondo (Author), David Rye (Author), Jerome M. Siegel (Author), Alessandro Silvani (Author), John W. Winkelman (Author), Richard P. Allen (Author), Sergi Ferré (Author), the International Restless Legs Syndrome Study Group (IRLSSG) (Author)
• Format: Book
• Published: The Company of Biologists, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have prev...