The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen <i>Pseudomonas aeruginosa</i> with Low Cytotoxicity

• Główni autorzy: Vanessa Mildenberger (Autor), Daniel Alpízar-Pedraza (Autor), Ernesto M. Martell-Huguet (Autor), Markus Krämer (Autor), Grigory Bolotnikov (Autor), Anselmo J. Otero-Gonzalez (Autor), Tanja Weil (Autor), Armando Rodriguez-Alfonso (Autor), Nico Preising (Autor), Ludger Ständker (Autor), Verena Vogel (Autor), Barbara Spellerberg (Autor), Ann-Kathrin Kissmann (Autor), Frank Rosenau (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The diminishing portfolio of mankind's available antibiotics urges science to develop novel potent drugs. Here, we present a peptide fitting the typical blueprint of amphipathic and membrane-active antimicrobial peptides, denominated C14R. This 2 kDa peptide consists of 16 amino acid residues,...