The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen <i>Pseudomonas aeruginosa</i> with Low Cytotoxicity

• Main Authors: Vanessa Mildenberger (Author), Daniel Alpízar-Pedraza (Author), Ernesto M. Martell-Huguet (Author), Markus Krämer (Author), Grigory Bolotnikov (Author), Anselmo J. Otero-Gonzalez (Author), Tanja Weil (Author), Armando Rodriguez-Alfonso (Author), Nico Preising (Author), Ludger Ständker (Author), Verena Vogel (Author), Barbara Spellerberg (Author), Ann-Kathrin Kissmann (Author), Frank Rosenau (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2024-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The diminishing portfolio of mankind's available antibiotics urges science to develop novel potent drugs. Here, we present a peptide fitting the typical blueprint of amphipathic and membrane-active antimicrobial peptides, denominated C14R. This 2 kDa peptide consists of 16 amino acid residues,...