miR‐422a suppresses SMAD4 protein expression and promotes resistance to muscle loss

• Main Authors: Richard Paul (Author), Jen Lee (Author), Anna V. Donaldson (Author), Martin Connolly (Author), Mohammad Sharif (Author), Samantha Amanda Natanek (Author), Ulrich Rosendahl (Author), Michael I. Polkey (Author), Mark Griffiths (Author), Paul R. Kemp (Author)
• Format: Book
• Published: Wiley, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Loss of muscle mass and strength are important sequelae of chronic disease, but the response of individuals is remarkably variable, suggesting important genetic and epigenetic modulators of muscle homeostasis. Such factors are likely to modify the activity of pathways that regula...