Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Curves in their Antitumor Profiles

• Main Authors: Kashi Javaherian (Author), Tong-Young Lee (Author), Robert M. Tjin Tham Sjin (Author), George E. Parris (Author), Lynn Hlatky (Author)
• Format: Book
• Published: SAGE Publishing, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis refers to growth of blood vessels from pre-existing ones. In 1971, Folkman proposed that by choking off the blood supply to tumors, they are starved, leading to their demise. A few years ago, the monoclonal antibody Avastin became the first antiangiogenic biological approved by FDA, for...