Development and validation of liquid chromatography-tandem mass spectrometry method to quantify dasatinib in plasma and its application to a pharmacokinetic study

• Main Authors: Edlaine Rijo Costa (Author), Thales Nascimento Castro (Author), Cassiano Felippe Gonçalves- (Author), Hugo Caire de Castro Faria Neto (Author), José Carlos Saraiva Gonçalves (Author), Rita de Cássia Elias Estrela (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Dasatinib, a potent oral multi-targeted kinase inhibitor against Src and Bcr-Abl, can decrease inflammatory response in sepsis. A simple and cost-effective method for determination of an effective dose dasatinib was established. This method was validated in human plasma, with the aim of red...