CP-25, a Novel Anti-inflammatory and Immunomodulatory Drug, Inhibits the Functions of Activated Human B Cells through Regulating BAFF and TNF-alpha Signaling and Comparative Efficacy with Biological Agents

• Main Authors: Feng Zhang (Author), Jin-Ling Shu (Author), Ying Li (Author), Yu-Jing Wu (Author), Xian-Zheng Zhang (Author), Le Han (Author), Xiao-Yu Tang (Author), Chen Wang (Author), Qing-Tong Wang (Author), Jing-Yu Chen (Author), Yan Chang (Author), Hua-Xun Wu (Author), Ling-Ling Zhang (Author), Wei Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paeoniflorin-6'-O-benzene sulfonate (code: CP-25) was the chemistry structural modifications of Paeoniflorin (Pae). CP-25 inhibited B cells proliferation stimulated by B cell activating factor belonging to the TNF family (BAFF) or Tumor necrosis factor alpha (TNF-alpha). CP-25, Rituximab and Et...