Co-existence of two plasmids harboring transferable resistance-nodulation-division pump gene cluster, tmexCD1-toprJ1, and colistin resistance gene mcr-8 in Klebsiella pneumoniae

• Main Authors: Xiaofen Mo (Author), Hui Zhang (Author), Junfeng Fan (Author), Linna Xu (Author), Hao Fu (Author), Junpeng Yue (Author), Kaixuan Dong (Author), Qixia Luo (Author), Fen Wan (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The emergence of plasmid-mediated mobile colistin resistance (mcr) gene poses a great challenge to the clinical application of polymyxins. To date, mcr-1 to mcr-10 have been found in animals, humans, and the environment. Among them, mcr-8 was first identified in Klebsiella pneumo...