Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

• Main Authors: Melissa Touvron (Author), Brigitte Escoubet (Author), Mathias Mericskay (Author), Aude Angelini (Author), Luciane Lamotte (Author), Maria Paola Santini (Author), Nadia Rosenthal (Author), Dominique Daegelen (Author), David Tuil (Author), Jean-François Decaux (Author)
• Format: Book
• Published: The Company of Biologists, 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some benefi...