Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction

• Main Authors: Felipe T. Lee-Montiel (Author), Alexander Laemmle (Author), Verena Charwat (Author), Laure Dumont (Author), Caleb S. Lee (Author), Nathaniel Huebsch (Author), Hideaki Okochi (Author), Matthew J. Hancock (Author), Brian Siemons (Author), Steven C. Boggess (Author), Ishan Goswami (Author), Evan W. Miller (Author), Holger Willenbring (Author), Kevin E. Healy (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Fag: article
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Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ function in vitro are an emerging alternative to conventional monolayer cell culture and animal models for drug development. Human induced pluripotent stem cells (hiPSCs) have the potential to capture the diversity of hum...