Bactericidal activity does not predict sterilizing activity: the case of rifapentine in the murine model of Mycobacterium ulcerans disease.

• Autori principali: Deepak V Almeida (Autore), Paul J Converse (Autore), Si-Yang Li (Autore), Sandeep Tyagi (Autore), Eric L Nuermberger (Autore), Jacques H Grosset (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Since 2004, treatment of Mycobacterium ulcerans disease, or Buruli ulcer, has shifted from surgery to daily treatment with streptomycin (STR) + rifampin (RIF) for 8 weeks. For shortening treatment duration, we tested the potential of daily rifapentine (RPT), a long-acting rifamycin derivative, as a...