Rapid and specific chromatography method on monolithic RP-column for determination of high-dose methotrexate pharmacokinetics in sera of cancer patients admitted to Shiraz Amir Hospital

• Main Authors: Lida Shojaei (Author), Fakhrsadat Farvadi (Author), Soheila Zareifar (Author), Samirasadat Abolmaali (Author), Soha Namazi (Author), Alimohammad Tamaddon (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: methotrexate (MTX) is a routinely used antifolate for the treatment of solid tumors and hematologic malignancies. However, high-dose MTX can lead to severe side effects and the patients are required to receive leucovorin rescue. Hence, we aimed to develop a fast and specific HPLC metho...