Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases
<i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous viru...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2023-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous virulence factors that facilitate its success in the infectious process. Although the interactions between <i>A. baumannii</i> and the pulmonary epitheliums have been extensively studied, a complete and specific description of its overall pathogenic process is lacking. In this review, we summarize the current knowledge of the antibiotic resistance and virulence factors of <i>A. baumannii</i>, specifically focusing on the pathogenic mechanisms of this detrimental pathogen in respiratory infectious diseases. An expansion of the knowledge regarding <i>A. baumannii</i> pathogenesis will contribute to the development of effective therapies based on immunopathology or intracellular signaling pathways to eliminate this harmful pathogen during infections. |
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| Item Description: | 10.3390/antibiotics12121749 2079-6382 |