Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis

• Main Authors: Ling Chen (Author), Xuejie Huan (Author), Fengju Jia (Author), Zhen Zhang (Author), Mingxia Bi (Author), Lin Fu (Author), Xixun Du (Author), Xi Chen (Author), Chunling Yan (Author), Qian Jiao (Author), Hong Jiang (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OTU domain-containing protein 3 (OTUD3) knockout mice exhibited loss of nigral dopaminergic neurons and Parkinsonian symptoms. However, the underlying mechanisms are largely unknown. In this study, we observed that the inositol-requiring enzyme 1α (IRE1α)-induced endoplasmic reticulum (ER) stress wa...