Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

• Main Authors: Xiao-Tao He (Author), Kai-Xiang Zhou (Author), Wen-Jun Zhao (Author), Chen Zhang (Author), Jian-Ping Deng (Author), Fa-Ming Chen (Author), Ze-Xu Gu (Author), Yun-Qing Li (Author), Yu-Lin Dong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in...