Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

• প্রধান লেখক: Xiao-Tao He (লেখক), Kai-Xiang Zhou (লেখক), Wen-Jun Zhao (লেখক), Chen Zhang (লেখক), Jian-Ping Deng (লেখক), Fa-Ming Chen (লেখক), Ze-Xu Gu (লেখক), Yun-Qing Li (লেখক), Yu-Lin Dong (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in...