Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics

• Main Authors: Vasileios Oikonomou (Author), Giorgia Renga (Author), Antonella De Luca (Author), Monica Borghi (Author), Marilena Pariano (Author), Matteo Puccetti (Author), Giuseppe Paolicelli (Author), Claudia Stincardini (Author), Claudio Costantini (Author), Andrea Bartoli (Author), Teresa Zelante (Author), Luigina Romani (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phagocytes fight fungi using canonical and noncanonical, also called LC3-associated phagocytosis (LAP), autophagy pathways. However, the outcomes of autophagy/LAP in shaping host immune responses appear to greatly vary depending on fungal species and cell types. By allowing efficient pathogen cleara...