Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism

• Hoofdauteurs: Qin Yang (Auteur), Li Gao (Auteur), Xiao-wei Hu (Auteur), Jia-nan Wang (Auteur), Yao Zhang (Auteur), Yu-hang Dong (Auteur), Hui Yao Lan (Auteur), Xiao-ming Meng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Karger Publishers, 2021-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background: Transforming growth factor-β (TGF-β)/Smad signaling is the central mediator in renal fibrosis, yet its functional role in acute kidney injury (AKI) is not fully understood. Recent evidence showed that TGF-β/Smad3 may be involved in the pathogenesis of AKI, but its functional role and mec...