Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism

• Main Authors: Qin Yang (Author), Li Gao (Author), Xiao-wei Hu (Author), Jia-nan Wang (Author), Yao Zhang (Author), Yu-hang Dong (Author), Hui Yao Lan (Author), Xiao-ming Meng (Author)
• Format: Book
• Published: Karger Publishers, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Transforming growth factor-β (TGF-β)/Smad signaling is the central mediator in renal fibrosis, yet its functional role in acute kidney injury (AKI) is not fully understood. Recent evidence showed that TGF-β/Smad3 may be involved in the pathogenesis of AKI, but its functional role and mec...