Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

• Main Authors: Erin L. Crowgey (Author), Nitin Mahajan (Author), Wing Hing Wong (Author), Anilkumar Gopalakrishnapillai (Author), Sonali P. Barwe (Author), E. Anders Kolb (Author), Todd E. Druley (Author)
• Format: Book
• Published: BMC, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smal...