Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

• Main Authors: Josef Oeckl (Author), Petra Janovska (Author), Katerina Adamcova (Author), Kristina Bardova (Author), Sarah Brunner (Author), Sebastian Dieckmann (Author), Josef Ecker (Author), Tobias Fromme (Author), Jiri Funda (Author), Thomas Gantert (Author), Piero Giansanti (Author), Maria Soledad Hidrobo (Author), Ondrej Kuda (Author), Bernhard Kuster (Author), Yongguo Li (Author), Radek Pohl (Author), Sabine Schmitt (Author), Sabine Schweizer (Author), Hans Zischka (Author), Petr Zouhar (Author), Jan Kopecky (Author), Martin Klingenspor (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Classical ATP-independent non-shivering thermogenesis enabled by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in the cold. It has long been suspected that futile ATP-consuming substrate cycles also contribute to thermogenesis and...