Sensitive and rapid determination of amantadine without derivatization in human plasma by LC-MS/MS for a bioequivalence study

• Main Authors: Abhaysingh Bhadoriya (Author), Shivprakash Rathnam (Author), Bhavesh Dasandi (Author), Dharmesh Parmar (Author), Mallika Sanyal (Author), Pranav S. Shrivastav (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 µL plasma by...