Utilizing liposomal encapsulation approach to address nephrotoxic challenges of colistimethate sodium through a preclinical study

• Main Authors: Raktham Mektrirat (Author), Noppanut Paengjun (Author), Peerawit Chongrattanameteekul (Author), Sonthaya Umsumarng (Author), Suppara Cheunsri (Author), Kornravee Photichai (Author), Kittima Lewchalermvong (Author), Chalutwan Sansamur (Author), Siriporn Okonogi (Author), Wasan Katip (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of Colistin, a last-resort antimicrobial drug, carries the risk of acute kidney injury. The objective of the study was to assess the effectiveness of colistin-encapsulated liposomes (CL) in reducing nephrotoxicity. Additionally, a liposomal preparation of colistimethate sodium was formulated...