Predominant Promotion by Tacrolimus of Chondrogenic Differentiation to Proliferating Chondrocytes

• Main Authors: Yukari Nakamura (Author), Takeshi Takarada (Author), Ayumi Kodama (Author), Eiichi Hinoi (Author), Yukio Yoneda (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus (FK506) has been used as a therapeutic drug beneficial for the treatment of rheumatoid arthritis in humans. In this study, we investigated the effects of FK506 on cellular differentiation in cultured chondrogenic cells. Culture with FK506 led to a significant and concentration-dependent i...