Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

• Main Authors: Vladimír Kubíček (Author), Lenka Skálová (Author), Adam Skarka (Author), Věra Králová (Author), Jana Holubová (Author), Jana Štěpánková (Author), Zdeněk Šubrt (Author), Barbora Szotáková (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more information about FLU reduction in human liver, because this information has bee...