Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Bladder pain is frequently associated with bladder inflammation, as in conditions like interstitial cystitis (IC), for which current analgesic therapies have limited efficacy. The antinociceptive effect of alpha-2-delta (α2δ) ligands on inflammation-associated visceral pain like that experienced in...

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Main Authors: Ludivine Boudieu (Author), Sarah Mountadem (Author), Amandine Lashermes (Author), Mathieu Meleine (Author), Lauriane Ulmann (Author), François Rassendren (Author), Youssef Aissouni (Author), Benoit Sion (Author), Frédéric Antonio Carvalho (Author), Denis Ardid (Author)
Format: Book
Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
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3rd Floor Main Library

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