CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease

• Main Authors: Bence György (Author), Camilla Lööv (Author), Mikołaj P. Zaborowski (Author), Shuko Takeda (Author), Benjamin P. Kleinstiver (Author), Caitlin Commins (Author), Ksenia Kastanenka (Author), Dakai Mu (Author), Adrienn Volak (Author), Vilmantas Giedraitis (Author), Lars Lannfelt (Author), Casey A. Maguire (Author), J. Keith Joung (Author), Bradley T. Hyman (Author), Xandra O. Breakefield (Author), Martin Ingelsson (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The APPswe (Swedish) mutation in the amyloid precursor protein (APP) gene causes dominantly inherited Alzheimer's disease (AD) as a result of increased β-secretase cleavage of the amyloid-β (Aβ) precursor protein. This leads to abnormally high Aβ levels, not only in brain but also in peripheral...