Coleon U, Isolated from <i>Plectranthus mutabilis</i> Codd., Decreases P-Glycoprotein Activity Due to Mitochondrial Inhibition

• Main Authors: Sofija Jovanović Stojanov (Author), Epole N. Ntungwe (Author), Jelena Dinić (Author), Ana Podolski-Renić (Author), Milica Pajović (Author), Patrícia Rijo (Author), Milica Pešić (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance in cancer is often mediated by P-glycoprotein. Natural compounds have been suggested as a fourth generation of P-glycoprotein inhibitors. Coleon U, isolated from <i>Plectranthus mutabilis</i> Codd., was reported to modulate P-glycoprotein activity but the underlying...