Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages

• Main Authors: Pearl Moharil (Author), Zhuoya Wan (Author), Apurva Pardeshi (Author), Jiang Li (Author), Haozhe Huang (Author), Zhangyi Luo (Author), Sanjay Rathod (Author), Ziqian Zhang (Author), Yuang Chen (Author), Bei Zhang (Author), Christian A. Fernandez (Author), Jingjing Sun (Author), Song Li (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combination of passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. However, most reported polymeric systems have sizes above 100 nm, which limits effective extravasation into tumors that are poorly vascularized and have dense stroma. Th...