Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.

• मुख्य लेखकों: Andrew W Pountain (लेखक), Stefan K Weidt (लेखक), Clément Regnault (लेखक), Paul A Bates (लेखक), Anne M Donachie (लेखक), Nicholas J Dickens (लेखक), Michael P Barrett (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2019-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance to this drug is a considerable threat. Here we ch...