Pharmacokinetics, pharmacodynamics, and safety of izuforant, an H4R inhibitor, in healthy subjects: A phase I single and multiple ascending dose study

• 主要な著者: Byung Hak Jin (著者), Taegon Hong (著者), Byung Won Yoo (著者), Choon Ok Kim (著者), Dasohm Kim (著者), Youn Nam Kim (著者), Min Soo Park (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2024-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Izuforant is a selective, and potent histamine H4 receptor (H4R) antagonist developed to treat atopic dermatitis (AD). There is an unmet medical need for therapeutic agents to control inflammation and pruritus. Izuforant is a strong candidate for this task based on the findings of non‐clini...