DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis

• Главные авторы: Jia-Ying Yang (Автор), Dan-Yang Shen (Автор), Jun Wang (Автор), Jing-Feng Dai (Автор), Xiao-Yan Qin (Автор), Yang Hu (Автор), Rongfeng Lan (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Предметы: article
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The small molecule DAPT inhibits the Notch signaling pathway by blocking γ-secretase mediated Notch cleavage. Given the critical role of the Notch signaling axis in inflammation, we asked whether DAPT could block Notch-mediated inflammation and thus exert neuronal protection. We established a mouse...