DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis
The small molecule DAPT inhibits the Notch signaling pathway by blocking γ-secretase mediated Notch cleavage. Given the critical role of the Notch signaling axis in inflammation, we asked whether DAPT could block Notch-mediated inflammation and thus exert neuronal protection. We established a mouse...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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