Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide

• Main Authors: Hua Yang (Author), Feng Gao (Author), Brooke McNeil (Author), Chengcheng Zhang (Author), Zheliang Yuan (Author), Stefan Zeisler (Author), Joel Kumlin (Author), Jutta Zeisler (Author), François Bénard (Author), Caterina Ramogida (Author), Paul Schaffer (Author)
• Format: Book
• Published: SpringerOpen, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of this isotope, challenged by the presence of endogenous copper ch...