Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

• Main Authors: Nurit P Azouz (Author), Andrea Klingler (Author), Victoria Callahan (Author), Ivan Akhrymuk (Author), Katarina Elez (Author), Lluís Raich (Author), Brandon Henry (Author), Justin Benoit (Author), Stefanie Benoit (Author), Frank Noé (Author), Kylene Kehn-Hall (Author), Marc Rothenberg (Author)
• Format: Book
• Published: Case Western Reserve University, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main pro...