iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats.

• Main Authors: Jia Shen (Author), Si-Fei Yu (Author), Mei Peng (Author), De-Hua Lai (Author), Geoff Hide (Author), Zhong-Dao Wu (Author), Zhao-Rong Lun (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We previously demonstrated that inherent high expression levels of nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), plays an i...