Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

• Main Authors: Ghada H. Al-Ansary (Author), Wagdy M. Eldehna (Author), Hazem A. Ghabbour (Author), Sara T. A. Al-Rashood (Author), Khalid A. Al-Rashood (Author), Radwa A. Eladwy (Author), Abdullah Al-Dhfyan (Author), Maha M. Kabil (Author), Hatem A. Abdel-Aziz (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a-d was designed and synthesised, in an attempt to develop potent anticancer agent that can target...