Disruption of CSF2RA in the bovine preimplantation embryo reduces development and affects embryonic gene expression in utero

• Main Authors: Froylan Sosa (Author), Kyungjun Uh (Author), Jéssica N Drum (Author), Katy S Stoecklein (Author), Kimberly M Davenport (Author), M Sofia Ortega (Author), Kiho Lee (Author), Peter J Hansen (Author)
• Format: Book
• Published: Bioscientifica, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The hypothesis that colony-stimulating factor 2 (CSF2) plays a role in the preimplantation development of the bovine embryo was tested by evaluating consequences of inactivation of CSF2RA (the functional receptor in the embryo) for the development of embryos in utero. CRISPR/Cas9 was used to alter s...